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Lee, Yi-Jang

 

Lee, Yi-Jang   Professor
 

 

Ph.D., Molecular Pathology, University of Rochester  

 

Office : Experimental building Room B318

Phone:(02)2826-7189(office) (02)2826-7000 #5570(lab)

E-mail : yjlee2@ym.edu.tw 
 
Consultation time :  Tue 10:00 ~ 12:00
 
 
      
 
Field of Research

 

Research Interest

To explore the effects of exogenous cofilin expression on influence of radiosensitivity and invasiveness/metastasis of cancer cells established in the living animal model

 
Aademic Masterpiece (2013.6-2018.5)
  1. CHUN‑YUAN CHANG, SHI‑LONG CHANG, JYH‑DER LEU, YU‑CHAN CHANG, MICHAEL HSIAO, LIANG‑TING LIN, HAN‑NAN LIN and YI‑JANG LEE*. Comparison of cofilin‑1 and Twist‑1 protein expression in human non‑small cell lung cancer tissues. Oncol. Rep., 2019, 42(2):805-816. *: Corresponding author
  2. Chung-Yih Wang,  Chun-Yuan Chang, Chun-Yu Wang, Kaili Liu, Chia-Yun Kang, Yi-Jang Lee* and Wei R. Chen. N-Dihydrogalactochitosan Potentiates the Radiosensitivity of Liver Metastatic Tumor Cells Originated from Murine Breast Tumors. Int. J. Mol. Sci., 2019, 20, 5581. *: Corresponding author
  3. Chun-Yuan Chang, Chao-Cheng Chen, Liang-Ting Lin, Chi-Hsien Chang, Liang-Chen Chen, Hsin-Ell Wang, Te-Wei Lee and Yi-Jang Lee*. PEGylated liposome encapsulated rhenium-188 radiopharmaceutical inhibits proliferation and epithelial-mesenchymal transition of human head and neck cancer cells in vivo with repeated therapy (Accepted). Cell Death Discovery 2018; : (SCI).
  4. Liang-Tin Lin, Shin-Yi Liu, Jyh-Der Leu, Cheng-Yuan Chang, Shih-Hwa Chiou, Te-Chang Lee*, and Yi-Jang Lee*. Arsenic trioxide-mediated suppression of miR-182-5p is associated with potent anti-oxidant effects through up-regulation of SESN2. Oncotarget 2018; 9:16028-16042 (SCI). (* co-corresponding author)
  5. Hsin-Yu Chiu2#, Jyh-Der Leu1#, Chun-Yuan Chang2, Yi-Jang Lee*, and Wei R. Chen. Combination of radiofrequency ablation and glycated chitosan on treatment of the syngeneic breast tumor model. Anticancer Res. 2017: 37(6): 2965-2974 (SCI)
  6. Jyh-Der Leu, Bo-Shen Wang, Shu-Jun Chiu, Chung-Yun Chang, Chien-Chih Chen, Fu-Du Chen, Shiirevnyamba Avirmed, and Yi-Jang Lee*. Combination of fisetin and ionizing radiation suppresses the growth of mammalian colorectal cancers in the xenograft tumor model. Oncology Letters. 2016: 12(6): 4975-4982  (SCI)
  7. Baasansuren S, Po-Shen Wang, Ulziisaikhan E, Amarsaukhan S, Yi-Jang Lee, Shiirevnyamba A. Association between MDM2-SNP309 polymorphism and bladder cancer in Mongolians. Journal of Mongolian Medical Sciences. 2015:1 (171): 4-8. (OI)
  8.  Han-Wen Guo, Liang-Ting Lin, Po-Hsiung Chen, Meng-Huan Ho, Wan-Ting Huang, Yi-Jang Lee, Shih-Hwa Chiou, Yei-San Hsieh, Chen-Yuan Dong, Hsing-Wen Wang. Low-fluence rate, long duration photodynamic therapy in glioma mouse model using organic light emitting diode (OLED). Photodiagnosis and Photodynamic Therapy. 2015 : S1572-1000(15)00042-3. (SCI)
  9. Chun-Yuan Chang, Jyh-Der Leu, Yi-Jang Lee*. The actin depolymerizing factor (ADF)/cofilin signaling pathway and DNA damage responses in cancer. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2015; 16(2):4095-4120. (SCI) (*:corresponding author).
  10. Cheng-Han Tsai; Liang-Ting Lin; Chung-Yih Wang; Yu-Wen Chiu; Yen-Ting Chou; Shu-Jun Chiu; Hsin-Ell Wang; Ren-Shyan Liu; Chung-Yi Wu; Pei-Chia Chan; Muh-Hwa Yang; Shih-Hwa Chiou; Man-Jyun Liao; Yi-Jang Lee*. Over-expression of cofilin-1 suppressed growth and invasion of cancer cells is associated with up-regulation of let-7 microRNA . BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2015;1852(5):851-861 (SCI) (*:corresponding author)
  11. Liang-Ting Lin, Chih-Hsien Chang, Hsiang-Lin Yu, Ren-Shyan Liu, Hsin-Ell Wang, Shu-Jun Chiu, Fu-Du Chen, Te-Wei Lee*, Yi-Jang Lee*. Evaluation of the therapeutic and diagnostic effects of PEGylated liposomes embedded rhenium-188 on human non-small cell lung cancer using the small animal model. Journal of Nuclear Medicine 2014;55(11):1864-1870. (SCI) (*:co-corresponding author)
  12. En-Chi Liao, Ying-Ting Hsu, Qiu-Yu Chuah, Yi-Jang Lee, Jing-Yi Hu, Tsui-Chin Huang,Pei-Ming Yang,and Shu-Jun Chiu. Radiation induces senescence and a bystander effect through metabolic alterations. Cell Death and Disease. 5, e1255, 2014.
  13. Ying-Ling Chen, Chung-Yih Wang, Feng-Yi Yang, Bo-Sheng Wang, Jason Y. Chen, Liang-Ting Lin, Jyh-Der Leu, Shu-Jun Chiu, Fu-Du Chen, Yi-Jang Lee* , and Wei R. Chen*. Synergistic effects of the immunoadjuvant glycated chitosan with high-intensity focused ultrasound on suppression of metastases in a syngeneic breast tumor model. Cell Death and Disease. 5: e1178. 2014. (SCI) (*:co-corresponding author)
  14. Liang-Ting Lin, Bo-Sheng Wang, Jyh-Cheng Chen, Chi-Hsien Liu, Chien Chou, Shu-Jun Chiu, Wen-Yi Chang, Ren-Shyan Liu, C. Allen Chang, and Yi-Jang Lee*. mPlum fused infrared fluorescent protein 1.4 may display Forster resonance energy transfer associated properties that can be used for near-infrared based reporter gene imaging. Journal of Biomedical Optics, 18(12), 126013, 2013. (SCI)
  15. Yao-Huei Huang, Pei-Ming Yang, Qiu-Yu Chuah, Yi-Jang Lee, Yi-Fen Hsieh, Chih-Wen Peng and Shu-Jun Chiu. Autophagy promotes radiation-induced senescence but inhibits bystander effects in human breast cancer cells. Autophagy, 10(7):1212-28, 2014. (SCI)
  16. Ying-Feng Chang, Cheng-Han Chao, Lih-Yuan Lin, Cheng-Han Tsai, Chien Chou, and Yi-Jang Lee*. Determination of urine cofilin-1 level in acute kidney injury using a high-throughput fiber optic biosensor. Journal of Biomedical Optics, 19(1), 011004, 2013. (SCI)
  17. Yi-Chu Yu, Pei-Ming Yang, Qiu-Yu Chuah, Yao-Huei Huang, Chih-Wen Peng, Yi-Jang Lee and Shu-Jun Chiu. Radiation-induced senescence in securin-deficient cancer cells promotes cell invasion involving the IL-6/STAT3 and PDGF-BB/PDGFR pathways. Scientific Reports, 3, 1675, 2013. (SCI)
  18.  Wei-Hsun Wang, I-Tsang Chiang, Yu-Chang Liu, Fei-Ting Hsu, Hong-Wen Chen, Chuan-Lin Chen, Yi-Jang Lee, Wuu-Jyh Lin and Jeng-Jong Hwang. Simultaneous Imaging of Temporal Changes of NF-κB Activity and Viable Tumor Cells in Huh7/NF-κB-tk-luc2/rfp Tumor-bearing Mice. In Vivo, 27, 339-350, 2013. (SCI)
  19. Leu, Jyh-Der; Chiu, Yu-Wen; Lo, Chia-Chien; Chiang, Pei-Hsun; Chiu,Shu-Jun; sai, Cheng-Han; Hwang, J-J.; Chen, Ran-Chou; Gorbunova, Vera; Lee, Yi-Jang*. Enhanced cellular radiosensitivity induced by cofilin-1 over-expression is associated with reduced DNA repair capacity. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 89(6):433-444, 2013 (SCI)
  20. Ying-Ling Chen, Shiau-Yi Wang, Ren-Shyan Liu, Hsin-Ell Wang, Jyh-Cheng Chen, Shih-Hwa Chiou, C. Allen Chang, Liang-Ting Lin, David Tan Tat Wei and Yi-Jang Lee*. Remnant living cells that escape cell loss in late-stage tumors exhibit cancer stem cells-like characteristics. Cell Death & Disease. 3, e399; doi:10.1038/cddis.2012.136, 2012 (SCI)
  21. Liang-Ting Lin, Shih-Hwa Chiou, Te-Wei Lee5 Ren-Shyan Liu, Jeng-Jong Hwang, Chih-Hsien Chang, Hsin-I Ma, Yi-Jang Lee* A comparative study of primary and recurrent human glioblastoma multiforme using the small animal imaging and molecular expressive profiles. Molecular Imaging and Biology. 15:262-272, 2013 (SCI).