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Wang, Hsin-Ell

 

Wang, Hsin-Ell   Professor
 

 

Ph.D., Chemistry, National Taiwan University, ROC  

 

Office : Experimental building Room B328

Phone:(02)2826-7215(office) (02)2826-7000 #5596、#5234(lab)

E-mail : hewang@ym.edu.tw 
 
Consultation time : Mon, Fri 14:00 ~ 17:00
 
 
 
Field of Research
 
Research Interest

ZRadiation chemistry, Nuclear medical pharmacology, Nuclear medicine

 
Aademic Masterpiece
  1. Kuo-Hsiang Chuang, Hsin-Ell Wang# (co-first author), Ta-Chun Cheng, Shey-Cherng Tzou, Chiu-Min Cheng, Chien-Han Kao, Chih-Hung Chung, Wei-Lung Tseng, Wen-Chun Hung, Ming-Hong Tai, Tien-Kuei Chang, Bing-Mae Chen, Steve R. Roffler and Tian-Lu Cheng*. Development of a universal anti-polyethylene glycol reporter gene for noninvasive imaging of PEGylated probes. J Nucl Med (2010) 51:933-941.
  2. Kuo-Hsiang Chuang, Hsin-Ell Wang# (co-first author), Fang-Ming Chen, Shey-Cherng Tzou, Chiu-Min Cheng, Ya-Chen Chang, Wei-Lung Tseng, Jentaie Shiea, Shiu-Ru Lin, Jaw-Yuan Wang, Bing-Mae Chen8, Steve R. Roffler and Tian-Lu Cheng. Endocytosis of PEGylated agents enhances cancer imaging and anti-cancer efficacy. Mol Cancer Ther (2010) 9(6):1903-1912.
  3. Chien-Chung Hsia, Fu-Lei Huang, Cheng-Hsien Lin, Lie-Hang Shen and Hsin-Ell Wang*. The preparation and biological characterization of new HL91-derivative for hypoxic imaging on stroke mice. Appl Radiat Isot (2010) 68:1610-1615.
  4. Kang-Wei Chang; Chia-Chieh Chen; Shih-Ying Lee and Hsin-Ell Wang*. Development of acute and subacute toxicity with the serotonin transporter radiopharmaceutical, ADAM. Drugs and Chemical Toxicology (2010) 33:393-402.
  5. Shey-Cherng Tzou, Steve Roffler, Kuo-Hsiang Chuang, Hsin-Pei Yeh, Chien-Han Kao, Yu-Cheng Su, Chiu-Min Cheng, Wei-Lung Tseng, Jentaie Shiea, Kai-Wen Cheng, Bing-Mae Chen, Tian-Lu Cheng and Hsin-Ell Wang. Micro-PET imaging of β-glucuronidase activity by the hydrophobic conversion of a glucuronide probe. Radiology (2009) 252(3):754-62
  6. Kang-Wei Chang, Chia-Chieh Chen, Shih-Ying Lee and Hsin-Ell Wang*. Acute toxicity of two Alzheimer's disease radiopharmaceuticals: FDDNP and IMPY. Drugs and Chemical Toxicology (2009) 32(4):429-437
  7. Ren-Shyan Liu, Ta-Kai Chou, Chih-Hsien Chang, Chun-Yi Wu, Chi-Wei Chang, Tsui-Jung Chang, Shih-Jen Wang, Wuu-Jyh Lin and Hsin-Ell Wang. Biodistribution, Pharmacokinetics and PET Imaging of [18F]FMISO, [18F]FDG and [18F]FAc in a sarcoma- and inflammation-bearing mouse model. NUCLEAR MEDICINE AND BIOLOGY 2009;36:305-312 (SCI).(Impact factor: 2.478;Rank: 29.89%)
  8. Chi-Wei Chang, Yi-Yu Lin, Chi-Jung Peng, Mai Lin, Ren-Shyan Liu, Shyh-Jen Wang, Wuu-Jyh Lin and Hsin-Ell Wang*. The robotic radiosynthesis of 5-[18F]fluoro-2'- deoxyuridine and its biological characterization. APPLIED RADIATION AND ISOTOPES 2009;: (SCI).(Impact factor: 1.008;Rank: 25.81%)
  9. K.W.Chang, C.C.Chen, S.H.Lee, L.H.Shen and H.E.Wang*. The synthesis and characterization of [124I]IMPY, a thioflavin-S derivative, in transgenic mouse models of Alzheimer’s disease. APPLIED RADIATION AND ISOTOPES 2009;: (SCI).(Impact factor: 1.008;Rank: 25.81%)
  10. Chun-Yi Wu, Pei-Chia Chan, Wei-Ting Chang, Ren-Shyan Liu, Mian M Alauddin and Hsin-Ell Wang*. Radiosynthesis of F-18 labeled cytidine analogue 2'-fluoro-5-iodo-l-β-D- arabinofuranosylcytosine ([18F]FIAC). APPLIED RADIATION AND ISOTOPES 2009;: (SCI).(Impact factor: 1.008;Rank: 25.81%)
  11. Chia-Hung Hsieh, Fu-Du Chen, Hsin-Ell Wang, Jeng-Jong Hwang, Chi-Wei Chang, Yi-Jang Lee, Juri G. Gelovani, and Ren-Shyan Liu. Generation of Destabilized Herpes Simplex Virus Type 1 Thymidine Kinase as Transcription Reporter for PET Reporter Systems in Molecular–Genetic Imaging. JOURNAL OF NUCLEAR MEDICINE 2008;49:142-150 (SCI).(Impact factor: 5.915;Rank: 2.30%)
  12. Tong-Hsien Chow, Yi-Yu Lin, Jeng-Jong Hwang, Hsin-Ell Wang, Yun-Long Tseng, Victor Fei Pang, Shyh-Jen Wang, Jacqueline Whang-Peng, Gann Ting. Diagnostic and therapeutic evaluation of 111In-vinorelbine-liposomes in a human colorectal carcinoma HT-29/luc-bearing animal mode. NUCLEAR MEDICINE AND BIOLOGY 2008;35:623-634 (SCI).(Impact factor: 2.478;Rank: 29.89%)
  13. Ya-Ju Hsieh, Fu-Du Chen, Fu Hui Wang, Chien Chih Ke, Hsin-Ell Wang and Ren-Shyan Liu. Molecular switch of Cre/loxP for radiation modulated gene therapy on hepatoma. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT 2007;571:453-456 (SCI).(Impact factor: 1.114;Rank: 12.90%)
  14. Ya-Fang Chang, Yi-Yu Lin, Hsin-Ell Wang, Ren-Shyan Liu, Fei Pang and Jeng-Jong Hwang. Monitoring of tumor growth and metastasis potential in MDA-MB-435s/tk-luc human breast cancer xenografts. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT 2007;571:155-159 (SCI).(Impact factor: 1.114;Rank: 12.90%)
  15. C.W. Chang, T.K. Chou, R.S. Liu, S.J. Wang, W.J. Lin, C.H. Chen and H.E. Wang. A robotic synthesis of [18F]fluoromisonidazole ([18F]FMISO). APPLIED RADIATION AND ISOTOPES 2007;65:682-686 (SCI).(Impact factor: 1.008;Rank: 25.81%)
  16. Ya-Ju Hsieh, Ren-Shyan Liu, Luen Hwu, Chien Chih Ke, Fu Hui Wang, Hsin-Ell Wang and Fu-Du Chen. Cre/loxP system controlled by specific promoter for radiation-mediated gene therapy of hepatoma. ANTICANCER RESEARCH 2007;27:1571-1580 (SCI).(Impact factor: 1.414;Rank: 81.82%)
  17. Chi-Wei Chang, Mai Lin, Shih-Yen Wu, Chia-Hung Hsieh, Ren-Shyan Liu, Shyh-Jen Wang, Kuang-Liang Huang, Chin-Hsiung Chen, Hsin-Ell Wang. A high yield robotic synthesis of 9-(4-[18F]-fluoro-3-hydroxymethylbutyl)guanine ([18F]FHBG) and 9-[(3-[18F]fluoro- 1-hydroxy-2-propoxy)methyl]guanine ([18F]FHPG) for gene expression imaging. APPLIED RADIATION AND ISOTOPES 2007;65:57-63 (SCI).(Impact factor: 1.008;Rank: 25.81%)
  18. Steve R. Roffler, Hsin-Ell Wang, Hung-Man Yu, Wen-Da Chang, Chiu-Min Cheng, Yu-Ling Lu, Bing-Mae Chen, Tian-Lu Cheng. A membrane antibody receptor for noninvasive imaging of gene expression. Gene Therapy 2006;13:412~420 (SCI).(Impact factor: 4.812;Rank: 9.42%)
  19. Chih-Hsieh Chang, Mei Lin, Kuo-Hsien Fan, Hsin-Ell Wang, Tung-Hu Tsai, Chieh-Fu Chen, Ying-Kai Fu, Te-Wei Lee. Longitudinal evaluation of tumor metastasis by an FDG-microPET/microCT dual-imaging modality in a lung carcinoma-bearing mouse model. Anticancer Research 2006;26:159~166 (SCI).(Impact factor: 1.414;Rank: 81.82%)
  20. Chih-Hsien Chang, Hsin-Ell Wang, Shih-Yen Wu, Kuo-Hsien Fan, Tung-Hu Tsai, Te-Wei Lee, Chang SR, Ren-Shyan Liu, Chen CF, Chin-Hsiung Chen, Ying-Kai Fu. Comparative evaluation of 18F-FET and 18F-FDG for differentiating lung carcinoma from inflammation in mice. Anticancer Research 2006;26:917~926 (SCI).(Impact factor: 1.414;Rank: 81.82%)
  21. C.H. Hsieh, H.M. Liu, J.J. Hwang, H.E. Wang, J.J. Kai, F.D. Chen. A simple model for quantification of the radiobiological effectiveness of the 10B(n,a)7Li capture reaction in BNCT. APPLIED RADIATION AND ISOTOPES 2006;64:306~314 (SCI).(Impact factor: 1.008;Rank: 25.81%)
  22. Hung-Man Yu, Hsin-Pei Yeh, Tien-Kui Chang, Kuang-Liang Huang, Kuo-Tang Chuang, Ren-Shen Liu, Shyh-Jen Wang, Jeng-Jong Hwang, Kwan-Hwa Chi, Fu-Du Chen, Wuu-Jyh Lin, Chin-Hsiing Chen, Hsin-Ell Wang. Improved targeting of 5-[125I/131I]iodo-2'-deoxyuridine to rat hepatoma by using lipiodo emulsion. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT 2006;569:538-542 (SCI).(Impact factor: 1.114;Rank: 12.90%)
  23. Hsin-Ell Wang, Hung-Man Yu, Yi-Ching Lu, Ning-Ning Heish, Yun-Long Tseng, Kuang-Liang Huang, Kuo-Teng Chuang, Chin-Hsiung Chen, Jeng-Jong Hwang, Wuu-Jyh Lin, Shyh-Jen Wang, Gann Ting, Jacqueline Whang-Peng, Win-Ping Deng. Internal radiotherapy and dosimetry study for 111In/177Lu-pegylated liposomes conjugates in tumor-bearing mice. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT 2006;569:533-537 (SCI).(Impact factor: 1.114;Rank: 12.90%)
  24. Win-Ping Deng, Cheng-Chia Wu, Chien-Chih Lee, Wen K. Yang, Hsin-Ell Wang, Ren-Shyan Liu, Hon-Jian Wei, Juri G. Gelovani, Jeng-Jong Hwang, Den-Mei Yang, Ying-Kai Fu, and Cheng-Wen Wu. Serial In Vivo Imaging of the Lung Metastases Model and Gene Therapy Using HSV1-tk and Ganciclovir. JOURNAL OF NUCLEAR MEDICINE 2006;47:877-88 (SCI).(Impact factor: 5.915;Rank: 2.30%)
  25. Hsin-Ell Wang, Hung-Man Yu, Ren-Shyan Liu, Mai Lin, Juri G. Gelovani, Jeng-Jong Hwang, Hon-Jian Wei, Win-Ping Deng. Molecular imaging with 123I-FIAU, 18F-FUdR, 18F-FET and 18F-FDG for monitoring herpes simplex virus type 1 thymidine kinase and ganciclovir prodrug activation gene therapy of cancer. Journal of Nuclear Medicine 2006;47:1161~1171 (SCI).(Impact factor: 5.915;Rank: 2.30%)
  26. Chia-Hung Hsieh, Yu-Fang Chen, Fu-Du Chen, Jeng-Jong Hwang, Jyh-Cheng Chen, Ren-Shen Liu, Ji-Jung Kai, Hsin-Ell Wang. Evaluation of pharmacokinetics of 4-bromo-2-18F-fluoro-L-phenylalanine for boron neutron capture therapy in a glioma-bearing rat model with hyperomolar blood-brain berrier disruption. Journal of Nuclear Medicine 2005;46:2-18 (SCI).(Impact factor: 5.915;Rank: 2.30%)
  27. Hsin-Ell Wang, Shih-Yen Wu, Chi-Wei Chang, Ren-Shen Liu, Li-Chung Hwang, Te-Wei Lee, Jyh-Cheng Chen and Jeng-Jong Hwang.. Evaluation of F-18-labeled amino acid derivatives and [18F]FDG as PET probes in a brain tumor-bearing animal model(in press). Nuclear Medicine and Biology 2005;32(4):367~375 (SCI).(Impact factor: 2.478;Rank: 29.89%)
  28. Hsin-Ell Wang, Hui-Chuan Wu, Shang-Jyh Kao, Fan-Wei Tseng, Yu-Shan Wang, Hung-Man Yu , Shun-Lan Chou, Sang-Hue Yen and Kwan-Hwa Chi.. Modulation of 5-fluorouracil cytotoxicity through thymidylate synthase and NF-κB down-regulation and its application on the radiolabelled iododeoxyuridine therapy on human hepatoma cell. BIOCHEMICAL PHARMACOLOGY 2005;69:617-626 (SCI).(Impact factor: 4.006;Rank: 15.61%)
  29. Shang-Lung Dong, Tieh-Chi Chu, Hung-Man Yu, Yu-Hsiu Yeh, Gong-Yau Lan, Yung-Chien Lin, Hsin-Ell Wang, Sang-Hue Yen. Investigation of polymer BANG gel dosimetry using X-ray computed tomographic imaging. Journal of Medical and Biological Engineering 2005;25(1):1~6 (SCI).
  30. Ying-Ta Wu, Weir-Torn Jiang, Kuo-Ging Lin, Chun-Ming Huang, Chin-Hsin Chang, Ying-Ling Sun, Kuo-Hsien Fan, Wei-Chuan Hsu, Hsin-Ell Wang, Shwu-Bin Lin, Shui-Tein Chen. A new N-acetylgalacoprotein containing peptide as a targeting vehicle for mammalian hepatocytes via Asialoglycoprotein receptor endocytosis. Current Drug Delivery 2004;1:119~127 (SCI).
  31. Win-Ping Deng, Wen K. Yang, Wen-Fu Lai, Ren-Shyan Liu, Jeng-Jong Hwang, Den-Mei Yang, Ying-Kai Fu , Hsin-Ell Wang. Non-invasive in vivo imaging with radiolabeled FIAU for monitoring cancer gene therapy using herpes simplex virus type 1 thymidine kinase and ganciclovir. European Journal of Nuclear Medicine and Molecular Imaging 2004;31(1):99-109 (SCI).(Impact factor: 4.101;Rank: 9.20%)
  32. Kwan-Hwa Chi, Hsin-Ell Wang, Yu-Shan Wang, Shun-Lan Chou, Hung-Man Yu, Yu-Hwa Tseng, Ing-Ming Hwang and Wing-Yiu Lui. Antisense thymidilate synthase electrogene transfer to increase uptake of radiolabeled iododeoxyuridine in a murine model. Journal of Nuclear Medicine 2004;45:478-484 (SCI).(Impact factor: 5.915;Rank: 2.30%)
  33. Hsin-Ell Wang, Ai-Ho Liao, Win-Ping Deng, Pi-Fang Chang, Jyh-Cheng Chen, Fu-Du Chen, Ren-Shen Liu, Jin-Shin Lee, and Jeng-Jong Hwang. Evaluation of 4-Borono-2-18F-Fluoro-L-Phenylalanine-Fructose as a Probe for Boron Neutron Capture Therapy in a Glioma-Bearing Rat Model. Journal of Nuclear Medicine 2004;45:2-18 (SCI).(Impact factor: 5.915;Rank: 2.30%)
  34. J.C.Chen, S.M.Chang, F.Y.Hsu, H.E.Wang, R.S.Liu.. MicroPET-based pharmacokinetic analysis of the radiolabeled boron compound [18F]FBPA-F in rats with F98 glioma. Applied Radiation and Isotopes 2004;61:887-891 (SCI).(Impact factor: 1.008;Rank: 25.81%)
  35. C. C. Hsia, H. E. Wang, S. P. Wey, R. S. Liu and L. H. Shen.. Biodistribution study of 99mTc-HL91 in sarcoma-bearing mice. Ann. Nucl. Med. Sciences 2003;16(3):131-136 (OI).
  36. G. U. Hung, Y. C. Weng, W. Y. Lin, S. J. Wang, C. C. Hsia, S. P. Wey, H. E. Wang, C. H. Lin, L. H. Shen and G Ting.. Preliminary study of 99mTc-HL91 on a tumor mouse model. Ann. Nucl. Med. Sciences 2002;15(2):85-91 (OI).
  37. W.P Deng, C.H. Chang, W.F. Lai, H.E. Wang, G. Ting, W.K. Yang and R.S. Liu.. Non-invasive mapping of gene expression for gene therapy with molecular nuclear medicine imaging. Ann. Nucl. Med. Sciences. 2001;14(4):237-246 (OI).
  38. Kwan-Hwa Chi, Hsin-Ell Wang, Fu-Du Chen, Yee Chao, Ren-Shyan Liu, Shuan-Lan Chou, Yu-Shan Wang and Sang-Hue Yen.. Pre-Clinical Evaluation of Loco-Regional Delivery of Radiolabelled Iododeoxyuridine and Thymidylate Synthase Inhibitor in Hepatoma Model. Journal of Nuclear Medicine 2001;42:345-351 (SCI).(Impact factor: 5.915;Rank: 2.30%)
  39. F.D. Chen, B.T. Hsieh, H.E. Wang, Y.H Ou,W.K. Yang, J. Whang-Peng, R.S. Liu, F.F. Knapp, G. Ting and S.H. Yen.. Efficacy of Re-188-labeled sulphur colloid on prolongation of survival time in melanoma-bearing animals. Nuclear Medicine and Biology 2001;28:835-844 (SCI).(Impact factor: 2.478;Rank: 29.89%)
  40. F. D. Chen, M.C. Wu, H.E. Wang, J. J. Hwang, C. Y. Hong, Y. T. Huang, S. H. Yen and Y. H. Ou.. Sensitization of a tumor, but not normal tissue, to the cytotoxic effect of ionizing radiation using Panax Notoginseng extract. Ammerican Journal of Chinese Medecine 2001;29:517-524 (SCI).
  41. C.W. Chang, H.E. Wang, H.M. Lin, C.S. Chtsai, J.B. Chen and R.S. Liu. Robotic synthesis of 6-[18F]fluoro-dopa. Nucl. Med. Commun. 2000;21:799-802 (SCI).
  42. H. E. Wang, C. W. Chang and H. M. Lin, et al.. Radiosynthesis of 6-[18F]fluoro-L-FDOPA for dopaminergic function imaging with PET. Ann. Nucl. Med. Sciences 1999;12(1):1-6 (OI).
  43. H. E. Wang, K. H. Chi, S. H. Yen, F. D. Chen, W. L. Chow, K. L. Huang, S. P. Wey and G. Ting. The preparation and formulation study on 5-[125/131I]-iodo-2’-deoxyuridine radiopharmaceutical for hepatoma therapy. Therapeutic Radiology and Oncology 1998;5(4):285-291 (OI).
  44. S. J. Wang, W. Y. Lin and H. E Wang, et al.. The quality assurance test of 1-131 cellulose. Ann. Nucl. Med. Sciences 1995;8:1-131 (OI).
  45. S. C. Tsai, H. E. Wang, C. T. Huang, L.M.Yiin and S,T.Liu. Study of effects on the coordination of thioether ligands2 Stereospecific ligand substitutions in manganese(I) complexes. Chem. Ber 1995;128:151-155 (SCI).
  46. H. E. Wang, M. C. Cheng, S. M. Peng and S. T. Liu. Structure of p,p',S-[2,2-bis(diphenylphosphino)methy]-l- phenylthiopropane] tricarbonyltungsten (0). Acta Crystal 1995;C51:98-200 (SCI).
  47. 童永黔, 伍德馨, 王信二. 核能研究所迴旋加速器研製碘-123之系列核醫藥物研究. INER-T2065 1995;: (OI).
  48. 王美惠, 王信二, 陳敏男. 碘標幟血清白蛋白穩定性評估-新腸胃道出血診斷試劑之初步研究. INER-T2131 1995;: (OI).
  49. 王信二, 黃廣良, 吳俊彥, 蔡潤杰. 心肌造影劑對-碘苯基脂肪酸之研製, (1) 碘-123-IPPA 及 BMIPPA 之標幟與純化, . INER-T2142 1995;: (OI).
  50. 黃廣良, 王信二, 沈立漢. 鎝-99m-DMS核醫藥物體內輻射吸收劑量評估. 核子醫學雜誌1995;8:5-20 (OI).
  51. 李銘析, 王信二, 沈立漢, 黃亨通. 核研碘-123-碘化鈉膠囊劑之研製及線上品管分析. INER-T2146 1995;: (OI).
  52. 王信二, 沈立漢, 吳俊彥. 腎功能造影劑I-123-0IH之備製研究. INER-T1963 1994;:123-120 (OI).
  53. 王信二, 沈立漢, 丁幹. 放射性碘標幟技術回顧. INER-1196 1994;: (SCI).
  54. H. E. Wang, M. C. Cheng, G. H. Lee, S. M. Peng and S. T. Liu. Coordination of a tripodal phosphine sulfide P2S toward various transition metal ions. J. Organomet. Chem. 1993;445:171-179 (SCI).
  55. S. T. Liu, H. E. Wang, S. C. Tsai, G. J. Liu, et al.. Study of the effects on coordination of thioether sites 1 Complexation study of bromopentacarbonyl manganese (I) with tripodal P3-nSn (n=O-3) ligands. Organometallics 1993;12:2277-2283 (SCI).(Impact factor: 3.833;Rank: 13.95%)
  56. 信二, 沈立漢, 丁幹. Dopamine 受體藥物化學之現況與展望. 化學 1992;50(4):395-414 (OI).
  57. 丁幹, 王信二. 同位素與輻射應用. INER-T1622 1992;: (OI).
  58. H. E. Wang, C. Y. Liu, S. T. Liu, et al. Nitrogen-containing tripodal ligands. Phosphorus, Sulfur and Silicon 1992;69:201-211 (SCI).
  59. H. E. Wang, S. T. Liu, et al.. Synthesis and coordination of tripodal-containing copper(I) complexes. J. Chinese Chem. Soc. 1991;38:565-572 (SCI).
  60. S. T. Liu, H. E. Wang, et al. Unusual tripodal ligand Synthesis of 22-bis(diphenylphosphinomethyl)-l-phenylthio- propane and its group VI complexes. J. Organomet. Chern. 1989;376:333-342 (SCI).
  61. 張憲義, 王信二, 蔡瑞燦, 童永黔. 分析輻射源項之電腦程式探討. 台電核能月刊 1986;: (OI).
  62. H. E. Wang and Z. T. Tsai. MELCOR 110 and 150 Test calculations related to peach bottom plant TC2 Accident. INER-T1125 1986;: (OI).
  63. 王信二, 謝俊雄, 丁幹, 馬建宏, 朱樹恭. 放射性同位素工業應用-石化工業大型連續式氧化反應槽滯留時間之測定與攪拌效率評估. INER-T1000 1985;: (OI).
  64. 王信二, 謝俊雄, 蔡瑞燦, 林清科. 以乾餾法生產高比放射性強度碘-131之研究. INER-T0899 1983;: (OI).