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Hwang, Jeng-Jong

 

Hwang, Jeng-Jong   Professor
 

 

Ph.D., Radiological Health Sciences, Colorado State University, USA  

 

CURRENT POSITIONS

  -  Professor of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan

  -  Adjunct Professor of Nuclear Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan

  -  Adjunct Professor, Graduate Institute of Oncology, School of Medicine, National Taiwan University, Taipei, Taiwan

  -  Honorable Research Consultant, Mackay Memorial Hospital, Taipei, Taiwan.


EDUCATION

Ph.D., Radiological Health Sciences (Minors: Cellular and Molecular Biology), graduated with completion of 234 credits, Colorado State University, Fort Collins, Colorado, USA
M.S., Radiation Biology, National Tsing-Hua University, Hsinchu, Taiwan
B.S., Biology, Fu-Jen Catholic University, Taipei, Taiwan

 

Office : Research Building  Room B207

Phone:(O) (886) 2-28267064  (Fax) (886) 2-28201095 

               (lab)(886)2-28267000#5809

E-mail :  jjhwang@ym.edu.tw
 
 
 
Field of Research
 
Research Interest

Radiation biology, Molecular biology, Oncologic biology

 
Aademic Masterpiece
*: corresponding author

1.    Lin FJ, Leu MY, Hwang JJ (1989): Determination of possible doses to the gonads or fetus in pregnant patients during radiation therapy. J Formos Med Assoc, 98(5), 462-468.

2.    Hwang JJ, Hsia SM, Jirtle RL (1993): Induction of sister chromatid exchange and micronuclei in primary cultures of rat and human hepatocytes. Mutation Res, 286, 123-133.

3.    Hwang JJ* (1994): Genetic effect induced by ionizing radiation. INER Quarterly, 10, 26-33.

4.    Hwang JJ* (1995): Biological effects induced by very low dose ionizing radiation. 88th Conference of Fomosan Medical Association, 174-178.

5.    Hwang JJ*, Wang HS and Lin FJ (1996): Cell, tissue, tumor kinetics and its clinical applications. Therapeu Radiol Oncol, 3, 265-274.

6.    Yen TC, Hwang JJ*, Wang HS (1996): Chromosomal aberrations induced in human lymphocytes after iodine-131 treatment for diagnosis of hyperthyroidism. J Biomed Lab Sci, 8, 91-96.

7.    King KL, Hwang JJ, Chau GY, Tsay SH, Chi CW, Lee TG (1998): Ki-67 expression as a prognostic marker in patients with hepatocellular carcinoma. J Gastroen Hepatol, 13, 273-279.

8.    Hwang JJ*, Chen HE, Tzeng WF, Lin GL, Deng WP, Lin FJ (1998): The effects of menadione alone or combined with ionizing radiation on human hepatoma cells. Therapeut Radiol Oncol, 5, 101-109.

9.    Hwang JJ*, Lin GL, Sheu SC, Lin FJ (1999): Effect of ionizing radiation on liver mitochondrial respiratory functions in mice. Chinese Med J, 112(4), 340-344.

10.  Deng WP, Hwang JJ, Lin GL (1999): Radiation-induced gene regulation. Therapeut Radiol Oncol, 5, 221-232.

11.  Hwang JJ, Yen TC, Hsieh BT, Ting G (1999): Application of macroautoradiography and instantimage in radiopharmaceutical research. J Radioan Nucl Ch, 241, 581-587.

12.  Chang WP, Hsieh WH, Chen DP, Lin YP, Hwang JS, Hwang JJ (1999): Change in centromeric and acentromeric micronucleus frequencies in human populations after chronic radiation exposure. Mutagenesis, 14(4), 427-432.

13.  Hwang JJ*, Chen PY, Deng WP, Hwang JY, Lin GL, Lin FJ (1999): Combined treatment effect of 5-fluorouracil with ionizing radiation on human colorectal carcinoma cells. Therapeut Radiol Oncol, 6, 73-82.

14.  Hwang JJ* (2001): The application of radiobiology in the clinical radiation oncology. Gamma, 32, 3-9.

15.  Chen SK, Tsai MH, Lin CH, Hwang JJ, Chang WP (2001): Determination of 8-oxoguanine in individual cell nucleus of g-irradiated mammalian cells. Radiat Res, 155, 832-836.

16.  Hsieh WA, Lucas JN, Hwang JJ, Chan CC, Chang WP (2001): Biodosimetry using chromosomal translocations measured by FISH in a population chronically exposed to low dose-rate 60Co-irradiation. Int J Radiat Biol 77, 797-804.

17.  Chen FD, Wu MC, Wang HE, Hwang JJ, Hong CY, Huang YT, Yen SH, Ou YH (2001): Sensitization of a tumor, but not a normal tissue, to the cytotoxic effect of ionizing radiation using panax notoginseng extract. Amer J Chin Med 29(3-4), 517-524.

18.  Wong YK, Tang KT, Wu JC, Hwang JJ, Wang HS (2001): Stimulation of hyaluronan synthesis by interleukin-1 involves activation of protein kinase C II in fibroblasts from patients with Graves’ ophthalmopathy. J Cell Biochem 82, 58-67.

19.  Chan JYH, Chen LK, Chang JF, Ting HM, Goy C, Chen JL, Hwang JJ, Chen FD, Chen DJ, Ngo FQH (2001): Differential gene expression in a double-strand-break repair mutant XRS-5 defective in Ku80: analysis by cDNA microarray. J Radiat Res, 42, 371-385.

20.  Hwang JJ*, Liao MH, Yen TC, Pan WHT, Wey SP, Chen JC, Ting G (2002): Biodistribution study of [99mTc]TRODAT-1 alone or combined with other dopaminergic drugs in mice with macroautoradiography. Appl Radiat Isotopes, 57, 35-42.

21.  Jen MH, Hwang JJ, Yang JY, Nabyvanets YB, Hsieh WA, Tsai MH, Guo SD, Chang WP (2002): Micronuclei and nuclear anomalies in urinary exfoliated cells of subjects in radionuclides-contaminated regions. Mutat Res, 520, 39-46.

22.  Hsieh WA, Lin YA, Ni C, Hwang JJ, Chang WP (2002): Evaluation of the frequencies of chromosomal aberrations in a population exposed to prolonged low dose-rate 60Co -irradiation. Int J Radiat Biol, 78, 625-633.

23.  Lin KJ, Ye XX, Yen TC, Wey SP, Tzen KY, Ting G, Hwang JJ* (2002):Biodistribution study of [123I]ADAM in mice: correlation with whole body autoradiography. Nucl Med Biol, 29, 643-650.

24.  Hwang JJ*, Liao MH, Ngo FQH (2002): Autoradiography and its image application in radiopharmaceutical research. J Radiologic Tech, 26, 1-11.

25.  Dong SL, Chu TC, Lee JS, Lan GY, Wu TH, Yeh YH, Hwang JJ* (2002): Estimation of mean glandular dose from monitoring breast entrance skin air kerma using high sensitivity metal oxide semiconductor field effect transistor (MOSFET) dosimeter system in mammography. Appl Radiat Isotopes, 57, 791-799.

26.  Wang HE, Liao AH, Chang PF, Chen FD, Chen JC, Hwang JJ* (2002) [18F]FBPA (4-borono-2-[18F]fluoro-L-phenylalanine-fructose), a boron-containing drug designed specificly for boron neutron capture therapy. Research and Development in Neuron Capture Therapy, Proceeding of the 10th International Congress on Neuron Capture Therapy; 909-912.

27.  Chen HW, Lai KC, Lin FJ, Lai YL, Hwang JJ* (2003): Increase in HPRT mutation frequency in tongue cancer patients after radiotherapy: report of two cases. J Health Science, 5, 185-193.

28.  Wang HE, Liao AH, Deng WP, Chang PF, Chen FD, Liu RS, Chen JC, Lee JS, Hwang JJ* (2004): Evaluation of 4-borono-2-[18F]fluoro-L-phenylalanine-fructose as a probe for BNCT in glioma-bearing rat model. J Nucl Med, 45, 302-308.

29.  Ye XX, Chen JC, Liu RS, Wey SP, Lee JS, Chen CC, Fu YK, Ting G, Hwang JJ* (2004): Microautoraduography of [123I]ADAM in mice treated with fluoxetine and serotonin reuptake inhibitors. Nucl Med Biol, 31(5), 557-563.

30.  Deng WP, Yang WK, Lai WF, Liu RS, Hwang JJ, Yang DM, Fu YK, Wang HE (2004): Non-invasive in vivo imaging with radiolabelled FIAU for monitoring cancer gene therapy using herpes simplex virus type 1 thymidine kinase and ganciclovir. Eu J Nucl Med, 31, 99-109.

31.  Lin KJ, Yen TC, Wey SP, Hwang JJ, Ye XX, Tzen KY, Chen JC (2004): Characterization of the binding sites for 123I-ADAM and the relationship to the serotonin transporter in rat and mouse brains using quantitative autoradiography. J Nucl Med, 45, 673-681.

32.  Chang YF, Hwang JJ* (2004): Microarray biotechnology. Science Development, 381, 34-41.

33.  Ye XX, Hwang JJ, Shieh JF, Chen JC, Chou YT, Tu KY, Wey SP, Ting G (2004): In Vivo Quantification of bound [123I]ADAM to serotonin transporters in the brains of rabbits by SPECT. Nucl Med Biol, 31, 995-1003.

34.  Wang HE, Wu SY, Chang CW, Liu RS, Hwang LC, Lee TW, Chen CJ, Hwang JJ* (2005): Evaluation of F-18-labeled amino acid derivatives and [18F]FDG as PET probes in a brain tumor-bearing animal model. Nucl Med Biol, 32, 367-375.

35.  Chen HW, Chang YC, Lai YL, Chen YJ, Huang MJ, Leu YS, Fu YK, Wang LW, Hwang JJ* (2005): Plasma TGF-β1 levels in nasopharyngeal carcinoma patients treated with concurrent chemo-radiotherapy, Jpn J Clin Oncol, 35, 427-432.

36.  Hsieh CH, Chen YF, Cheng FD, Hwang JJ, Chen JC, Liu RS, Kai JJ, Chang CW, Wang HE (2005): Evaluation of pharmacokinetics of 4-borono-2-18F-fluoro-L-phenylalanine for boron neutron capture therapy in a glioma-bearing rat model with hyperosmolar blood-brain-barrier disruption. J Nucl Med, 46, 1858-1865.

37.  Ding LH, Shingyoji M, Chen F, Hwang JJ, Burma S, Lee C, Cheng J-F, Chen DJ (2005): Gene expression profiles of normal human fibroblasts after exposure to ionizing radiation: A comparative study of low and high doses. Radiat Res, 164, 17-26.

38.  Lin CT, Chen FD, Fu YK, Wang HE, Hwang JJ, Chen JC, Deng WP, Huang WS, Hwang LH, Chang CW, Liu RS (2005): In vivo gene expression imaging by using plasmid vector containing HSV1-tk genes. Ann Nucl Med Sci, 18, 85-92.

39.  Lee WC, Hwang JJ*, Tseng YL ,Wang HE, Chang YF, Lu YC, Ting G, Whang-Peng J, Wang SJ (2006): Therapeutic efficacy evaluation of 111In-VNB-liposome on human colorectal adenocarcinoma HT-29/luc mouse xenografts. Nucl Instrum Meth A, 569, 497-504.

40.  Wang HE, Yu HM, Lu YC, Heish NN, Tseng YL, Huang KL, Chuang KT, Chen CH, Hwang JJ, Lin WJ, Wang SJ, Ting G, Peng JW, Deng WP (2006): Internal radiotherapy and dosimetric study for 111In/177Lu-pegylated liposomes conjugates in tumor-bearing mice. Nucl Instrum Methods Phys Res A, 569, 533-537.

41.  Yu HM, Yeh HP, Chang TK, Huang KL, Chuang KT, Liu RS, Wang SJ, Hwang JJ, Chi KH, Chen FD, Lin WJ, Chen CH, Wang HE (2006): Improved targeting of 5-[125I/131I]iodo-2’-deoxyuridine to rat hepatoma by using lipiodol emulsion. Nucl Instrum Meth A, 569, 538-542.

42.  Deng WP, Wu CC, Lee CC, Yang WK, Wang HE, Liu RS, Wei HJ, Gelovani J, Hwang JJ, Yang DM, Fu YK, Wu CW (2006): Serial in vivo imaging of the lung metastases model and gene therapy using HSV1-tk and ganciclovir. J Nucl Med, 47, 877-884.

43.  Hwang JJ*, Wang HE, Fang HY, Chen FD, Liu RS, Ngo FQH (2006): Biodistribution of dual radiosensitizers [131I]iododeoxyuridine and [18F]misonidazole in KHT sarcoma-bearing mice: correlation with whole-body autoradiography. Int J Cancer Mol, 2, 37-43.

44.  Deng WP, Chao WM, Lai WF, Sun C, Chung CY, Wu CC, Lin IH, Hwang JJ, Wu CH, Chiu WT, Chen CY, Redpath JL (2006): Correction of malignant behavior of tumor cells by traditional Chinese herb medicine through a restoration of p53. Cancer Lett, 233, 315-327.

45.  Wang HE, Yu HM, Liu RS, Lin M, Gelovani JG, Hwang JJ, Wei HJ, Deng WP (2006): Molecular imaging with 123I-FIAU, 18F-FudR, 18F-FET, and 18F-FDG for monitoring Herpes Simplex virus type 1 thymidine kinase and ganciclovir prodrug activation gene therapy of cancer. J Nucl Med, 47, 1161-1171.

46.   Hsieh CH, Liu HM, Hwang JJ, Wang HE, Kai JJ, Chen FD (2006): A simple model for quantification of the radiobiological effectiveness of the 10B(n,a)7Li capture reaction in BNCT. Appl Radiat Isotopes, 64, 306-314.

47.  Hsieh CH, Liu RS, Wang HE, Hwang JJ, Deng WP, Chang CW, Chen FD (2006): In vitro evaluation of herpes simplex virus type 1 thymidine kinase reporter system in dynamic studies of transcriptional gene regulation. Nucl Med Biol, 33(5), 653-660.

48.  Chang YF, Lin YY, Wang HE, Liu RS, Pang F, Hwang JJ* (2007): Monitoring of tumor growth and metastasis potential in MDA-MB-435s-tk/luc human breast cancer xenografts. Nucl Instrum Meth A, 571, 155-159.

49.  Chen CC, Hwang JJ*, Ting G, Tseng YL, Wang SJ, Whang-Peng J (2007): Temporal monitoring and quantitative assessment of tumor burden growth using in vivo bioluminescence imaging. Nucl Instrum Meth A, 571, 437-441.

50.  Su YC, Chuang KH, Wang YM, Cheng CM, Lin SR, Wang JY, Hwang JJ, Chen BM, Chen KC, Rofler S, Cheng TL (2007): Gene expression imaging by enzymatic catalysis of a fluorescent probe via membrane-anchored b-gluculonidase. Gene Therapy, 14, 565-574.

51.  Liao AH, Hwang JJ, Li CH, Cheng WF, Li PC (2007): Noninvasive tumor imaging with high-frequency ultrasound and microPET in small animals. Ultrasonic Imaging, 29, 182-194.

52. Chen HW, Chang YC, Chen YJ, Huang MJ, Leu YS, Chang GH, Hwang JJ* (2008): Epstein-Barr virus infection and plasma transforming growth factor-b1 levels in head and neck cancers. Acta Oto-Laryngologica, 128(10):1145-1151.

53.  Hsieh CH, Chen FD, Wang HE, Hwang JJ, Chang CW, Lee YJ, Gelovani JG, Liu RS (2008): Generation of destabilized herpes simplex virus type 1 thymidine kinase as transcription reporter for positron emission tomography reporter systems in molecular-genetic imaging. J Nucl Med, 49, 142-150.

54.  Chow TH, Lin YY, Hwang JJ*, Wang HE, Tseng YL, Pang VF, Wang SJ, Whang-Peng J, Ting G (2008): Diagnostic and therapeutic evaluation of 111In-vinorelbine liposomes in a human colorectal carcinoma HT-29/luc-bearing animal model. Nucl Med Biol, 35, 623-634.

55.  Ma KH, Huang WS, Kuo YY, Peng CJ, Liu RS, Hwang JJ, Liu JC, Chen HJ, Shiue CY (2008): Validation of 4-[18F]-ADAM as a SERT imaging agent using micro-PET and autoradiography. Neuroimage, 45, 687-693.

56.  Tzou SC, Roffler S, Chuang KH, Yeh HP, Kao CH, Su YC, Cheng CM, Tseng WL, Shiea J, Harm IH, Cheng KW, Chen BM, Hwang JJ, Cheng TL, Wang HE (2009): Micro-PET imaging of b-glucuronidase activity by the hydrophobic conversion of a glucuronide probe. Radiology, 252, 754-762.

57.  Lee YJ, Tsai CH, Hwang JJ, Chiu SJ, Sheu TJ, Keng PC (2009): Involvement of a p53-independent and post-transcriptional up-regulation for p21WAF/CIP1 following destabilization of the actin cytoskeleton. Intl J Oncol, 34:581-589.

58.  Liu RS, Hsieh YJ, Ke CC, Chen FD, Hwu L, Wang FH, Hwang JJ, Chi CW, Lee CH, Yeh SH (2009): Specific activation of sodium/iodide symporter gene in hepatoma using alpha-fetoprotein promoter combined with hepatitis B virus enhancer (EIIAPA). Anticancer Res, 29:211-222.

59.  Chow TH, Lin YY, Hwang JJ*, Wang HE, Tseng YL, Wang SJ, Liu RS, Lin WJ, Yang CS, Ting G (2009): Improvement of biodistribution and therapeutic index via increase of polyethylene glycol on drug-carrying liposomes in an HT-29/luc xenografted mouse model. Anticancer Res, 29:2111-2120.

60.  Lin YY, Li JL, Chang CH, Lu YC, Hwang JJ, Tseng YL, Lin WJ, Ting G, Wang HE (2009): Evaluation of pharmacokinetics of 111In-labeled VNB-liposomes after intraperitoneal and intravenous administration in a tumor/ascites mouse model. Cancer Biother Radio, 24, 453-460.

61.  Chow TH, Lin YY, Hwang JJ*, Wang HE, Tseng YL, Pang VF, Liu RS, Lin WJ, Yang CS, Ting G (2009): Therapeutic efficacy evaluation of 111In-labeled pegylated liposomal vinorelbine in murine colon carcinoma with multimodalities of molecular imaging. J Nucl Med, 50, 2073-2081.

62.  Lin YC, Chen HW, Kuo YC, Chang YF, Hwang JJ* (2010): Therapeutic efficacy evaluation of curcumim on human oral squamous cell carcinoma xenograft using multimodalities of molecular imaging. Am J Chin Med, 38, 343-358. (IF: 2.755; Rank: 29/154 in Medicine, General & Internal)

63.  Liao AH, Chou FI, Kuo YC, Chen HW, Kai JJ, Chang CW, F.D. Chen FD, Hwang JJ* (2010): Biodistribution of phenylboric acid derivative entrapped lipiodol and 4-borono-2-18F-fluoro-L-phenylalanine-fructose in GP7TB liver tumor bearing rats for BNCT. Appl Radiat Isotopes, 68, 422-426.

64.  Chuang HY, Chang YF, Hwang JJ* (2011): Antitumor effect of orlistat, a fatty acid synthase inhibitor, is via activation of caspase-3 on human colorectal carcinoma-bearing animal. Biomed Phamacother, 45:100-110.

65.  Kuo YC, Chiu YM, Shih WP, Yu HW, Chen CW, Wong PF, Lin WC, Hwang JJ* (2011): Volumetric intensity-modulated Arc (RapidArc) therapy for primary hepatocellular carcinoma: comparison with intensity-modulated radiotherapy and 3-D conformal radiotherapy. Radiation Oncology, 6:76-84. (IF: 2.546; Rank: 40/125 in Radiology, Nuclear Medicine & Medical Imaging)

66.  Hung MC, Hsieh WA, Chang PW, Hwang JJ* (2011): Utilization of nuclear medicine scintigraphy in Taiwan, 1997-2009. Ann Nucl Med, 25: 818-824.

67.  Kuo YC, Lin WC, Chiang IT, Chang YF, Chen CW, Su SH, Chen CL, Hwang JJ* (2012): Sorafenib sensitizes human colorectal carcinoma to radiation via suppression of NF-kB expression in vitro and in vivo. Biomed Phamacother, 66, 12-20.

68.  Chang YF, Chuang HY, Hsu CH, Liu RS, Gambhir SS*, Hwang JJ* (2012): Immunomodulation of curcumin on adoptive therapy with T cell functional imaging in mice. Cancer Prev Res, 5(3), 444-452. (IF: 4.444; Rank: 42/211 in Oncology)

69.  Wang WH, Chiang IT, Ding K, Chung JG, Lin WJ, Lin SS, Hwang JJ* (2012): Curcumin-induced apoptosis in human hepatocellular carcinoma J5 cells: critical Role of Ca+2 dependent pathway. Evidence-Based Complementary and Alternative Medicine, doi: 10.1155/2012/512907. (IF: 1.880; Rank: 7/24 in Integrative & Complementary Medicine)

70.  Liu YC, Chiang IT, Hsu FT, Hwang JJ* (2012): Using NF-κB as a molecular target for theranostics in radiation oncology research. Expert Review of Molecular Diagnostics, 12, 139-146. (IF: 3.516; Rank: 15/76 in Pathology)

71.  Chen HW, Chang YF, Chuang HY, Tai WT, Hwang JJ* (2012): Targeted therapy with fatty acid synthase inhibitors in a human prostate carcinoma LNCaP/tk-luc bearing animal model. Prostate Cancer and Prostatic Diseases, 15, 260-264. (IF: 3.425; Rank: 16/78 in Urology & Nephrology)

72.  Lin WC, Chang YC, Chang CY, Cheng YC, Hwang JJ* (2012): Primary lung cancers < 1 cm found with MR screening appeared larger with half-Fourier sequences than with three-dimensional acquisitioned techniques. Clinical Imaging, 36, 739-745.

73.  Hung MC, Chang PW, Hsieh WA, Hwang JJ* (2012): Myocardial perfusion scintigraphy in Taiwan from 2005 to 2009. Nuclear Medicine and Communication, 33, 733-738.

74.  Chiang IT, Liu YC, Wang WH, Hsu FT, Chen HW, Lin WJ, Chang WY and Hwang JJ* (2012): Sorafenib inhibits TPA-induced MMP-9 and VEGF expressions via suppression of ERK/NF-κB pathway in human hepatocellular carcinoma cells. IN VIVO, 26, 671-682.

75.  Fang CK, Chen HW, Chen CC, Liao JF, Su TP, Tung CY, Uchitomi Y, Hwang JJ* (2012): Mirtazapine inhibits tumor growth via immune response and serotonergic system. PLoS ONE, 7(7): e38886. Doi:10.1371/journal.pone.0038886 (IF: 3.234; Rank: 9/57 in Multidisciplinary Sciences)

76.  Lin YC, Hwang JJ, Wang SJ, Yang BH, Chang CW, Hsiao MC, Chou FI (2012): Macro- and micro-distributions of boron drug for boron neutron capture therapy in an animal model. Anticancer Research, 32, 2657-2664.

77.  Lin LT, Chiou SH, Lee TW, Liu RS, Hwang JJ, Chang CH, Ma HI, Lee YJ (2012): A comparative study of primary and recurrent human glioblastoma multiforme using the small animal imaging. Molecular Imaging & Biology, 15(3), 262-272.

78.  Tsao CH, Wu CY, Wang HE, Hwang JJ, Shih BF, Liu RS (2013): PET imaging of acute bacterial infection with F-18 fluoroacetate in a mouse model. Ann Nucl Med Sci, 26(2), 55-60.

79.  Fang CK, Chen HW, Wang WH, Liu RS, Hwang JJ* (2013): Acute effects of three club drugs on the striatum of rats: evaluation by quantitative autoradiography with [18F]FDOPA. Applied Radiation Isotopes, 77, 153-159.

80.  Leu JD, Chiu YW, Lo CC, Chiang PH, Chiu SJ, Tsai CH, Hwang JJ, Chen RC, Gorbunova V, Lee YJ (2013): Enhanced cellular radiosensitivity induced by cofilin-1 over-expression is associated with reduced DNA repair capacity. International Journal of Radiation Biology, 89(6), 433-444.

81.  Wang WH, Chiang IT, Liu YC, Hsu FT, Wang HE, Liu RS, Lin WJ, Hwang JJ* (2013): Simultaneous imaging of temporal change of NF-κB activity and viable tumor cells in Huh7/NF-κB-tk-luc2/rfp tumor-bearing animal. IN VIVO, 27 (3) 339-350.

82.  Chen HW, Hsu FT, Chang YC, Tu HF, Fang CK, Kuo SP, Hwang JJ* (2013): Variant frequency of HPRT gene in oral cancer patients treated with radiotherapy. Adaptive Medicine, 5(2), 83-91.

83. Lin YY, Kao HW, Li JJ, Hwang JJ, Tseng YL, Lin WJ, Lin MH, Ting G, Wang HE (2013): Tumor burden talks in cancer treatment with PEGylated liposomal drugs. PLoS ONE, 8(5):e63078. DOI:10.1371/journal.pone.0063078 pp.e63078 (IF: 3.234; Rank: 9/57 in Multidisciplinary Sciences)

84.  Hung MC, Hwang JJ (2013): Cancer risk from medical radiation procedures for coronary artery disease: a nationwide population-based cohort study. Asian Pacific Journal of Cancer Prevention, 14(5), 2783-2787.

85.  Chiang IT, Liu YC, Hsu FT, Kao CH, Lin WJ, Chung JG, Hwang JJ* (2014): Curcumin synergistically enhances radiosensitivity of human oral squamous cell carcinoma via suppression of radiation-induced NF-κB activity. Oncology Reports, 31, 1729-1737.

86.  Hung MC, Hwang JJ, Liu SS, Kao CH (2014): The longitudinal trend in the utilization of nuclear medicine for theranostics in Taiwan. Annal Nucl Med Mol Imag, 27, 12-22.

87.  Hsu FT, Liu YC, Chiang IT, Liu RS, Wang HE, Lin WJ, Hwang JJ* (2014): Sorafenib increases efficacy of vorinostat against human hepatocellular carcinoma through inhibition of vorinostat-induced ERK/NF-κB signaling transduction. International Journal of Oncology, 45, 177-188. (IF: 3.025; Rank: 96/211 in Oncology)

88.  Chien YC, Chen JCH, Lin WC, Ding HJ, Wang HE, Kao CHK, Hwang JJ* (2014): Using [18F]FBAU for imaging the brain tumor progression in a F98/tk-luc glioma-bearing rat model. Oncology Reports, 32, 691-699.

89.  Yeh SHH, Lin MH, Kong FL, Chang CW, Hwang LC, Lin CF, Hwang JJ*, Liu RS* (2014): Evaluation of inhibitory effect of recreational drugs on dopaminergic terminal neuron by PET and whole-body autoradiography. BioMed Research International, Article ID 157923.

90.   Hsu FT, Chang B, Chiang IT, Wu TH, Hwang JJ* (2014): Synergistic effect of sorafenib with ionizing radiation on human oral cancer cells. IN VIVO, 28(5), 925-933.

91.  Su YC, Yu CC, Hsu FT, Fu SL, Hwang JJ, Hung LC, Lee MS, Chiou WY, Lin HY, Hung SK (2014): Everolimus sensitizes Ras-transformed cells to radiation in vitro through the autophagy pathway. International Journal of Molecular Medicine, 34, 1417-1422. (IF: 2.348; Rank: 63/124 in Medicine, Research & Experimental).

92.  Fang CK, Chang YF, Chuang HY, Chen HW, Hwang JJ* (2014): Molecular imaging of neuropsychiatry and boron neutron capture therapy in neuro-oncology. Current Molecular Imaging, 3(1), 15-26.

93.  Chuang HY, Chang YF, Liu RS, Hwang JJ* (2014): Serial low-doses of sorafenib enhances therapeutic efficacy of adoptive T cell therapy in a murine model by improving tumor microenvironment. PLoS ONE, 9(10): e109992, doi: 10.1371/journal.pone.0109992. (SCI, IF=3.234, 8/56 in Multidisciplnary Sciences)

94.  Chan PC, Wu CY, Chou LS, Ho CH, Chang CW, Chiou SH, Lin WJ, Chen FD, Chang CA, Hwang JJ, Liu RS, Wang HE (2014): Monitoring tumor response after histone deacetylase inhibitor treatment using 3’-deoxy-3’-[18F]-fluorothymidine PET. Molecular Imaging and Biology, 16(1), 95-101.

95.  Wu TH, Lin WC, Chen WK, Chang YC, Hwang JJ* (2015): Predicting cancer risks from dental computed tomography. Journal of Dental Research, 94(1), 27-35. (IF: 4.139; Rank: 1/88 in Dentistry, Oral Surgery & Medicine)

96.  Hsu WC, Chien YC, Chang CH, Yuan TT, Lee TW, Hwang JJ* (2015): Characteristic comparison between 131I-interferon-α and 131I-interferon-α–immunoglobulin-Fc hybrid protein in rats using molecular imaging. IN VIVO, 29, 445-452.

97.  Hsu WC, Cheng CN, Lee TW, Hwang JJ* (2015): Cytotoxic effects of PEGylated anti-EGFR immunoliposomes combined with doxorubicin and rhenium-188 against cancer cells. Anticancer Research, 35, 4777-4788.

98.  Hsu FT, Liu YC, Liu TT, Hwang JJ* (2015): Curcumin sensitizes hepatocellular carcinoma cells to radiation via suppression of radiation-induced NF-kB activity. BioMed Research International, Article ID 363671.

99.  Hsu FT, Chang B, Chen J C-H, Chiang IT, Liu YC, Kwang WK, Hwang JJ* (2015): Synergistic Effect of Sorafenib and Radiation on Human Oral Carcinoma in vivo. Scientific Reports, 5:15391. DOI:10.1038/srep15391. (IF: 5.578; Rank: 5/56 in Multidisciplinary Sciences)

100. Chuang HY, Fang CK, Wang WH, Liu RS, Wang SJ, Hwang JJ* (2015): Chronic effects of cocaine on dopaminergic and serotonergic systems of rats. Current Molecular Imaging, 4(1), 43-52. DOI: 10.2174/2211555204666151103210332.

101. Yang FY*, Chang WY, Lin WT, Hwang JJ*, Chien YC, Wang HE, Tsai ML (2015):  Focused ultrasound enhanced molecular imaging and gene therapy for multifusion reporter gene in glioma-bearing rat model. Oncotarget, 6(34), 36260-36268. DOI: 10.18632/oncotarget.5389 (IF: 5.168; Rank: 44/217 in Oncology).

102. Hsu FT, Chen TC, Chuang HY, Chang YF, Hwang JJ* (2015): Enhancement of adoptive T cell transfer in mice with single low dose pretreatment of doxorubicin or paclitaxel in mice. Oncotarget, 6(42), 44134-44150. DOI: 10.18632/oncotarget.6628 (IF: 5.168; Rank: 44/217 in Oncology).

103. Wang WH, Chuang HY, Chen CH, Chen WK, Hwang JJ* (2016): Lupeol acetate ameliorates collagen-induced arthritis and osteoclastogenesis of mice through improvement of microenvironment. Biomedicine and Phamacotherapy, 79, 231-240.

104. Hung MC, Hwang JJ (2016): Utilization of nuclear medicine scintigraphy in Taiwan 1997-2009. Nuklearmedizin. DOI: http://dx.doi.org/10.3413/Nukmed-0778-15-11

105. Shen YA, Wang CY, Chuang HY, Hwang JJ, Chi WH, Shu CH, Ho CY, Li WY, Chen YJ (2016): CD44 and CD24 coordinate the reprogramming of nasopharyngeal carcinoma cells towards a cancer stem cell phenotype through STAT3 activation. Oncotarget, 7(36), 58351-58366. DOI: 10.18632/oncotarget.11113 (IF: 5.168; Rank: 44/217 in Oncology).

106. Chen JCH, Chuang HY, Hsu FT, Chen YC, Chien YC, Hwang JJ* (2016): Sorafenib pretreatment enhances radiotherapy through targeting MEK/ERK/NF-kB pathway in human hepatocellular carcinoma-bearing mouse model. Oncotarget 7(51), 85450-85463. (IF: 5.168; Rank: 44/217 in Oncology).

107. Chen JCH, Chuang HY, Liao YJ, Hsu FT, Chen YC, Wang WH, Hwang JJ* (2017): Enhanced Cytotoxicity of Human Hepatocellular Carcinoma Cells by Pretreatment of Sorafenib Combined with Trichostatin A. Oncology Letters (In press).