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Chang, Allen Cheng


Chang, Allen Cheng   Professor

Ph.D., Chemistry, University of Pittsburgh, USA


Office : Experimental building Room D308

Phone:(02)-28267000#7943(office) (02)2826-7000 #5120(lab)

Consultation time : mon, wed 15:00 ~ 18:00
Field of Research
Research Interest


Diagnostic imaging and molecular medicine, Bioinorganic and bioanalytical chemistry, Biomedical engineering


Aademic Masterpiece

A. 生物無機化學、診斷藥學、分子醫學:稀土離子之配位化學(大環配位子之合成和純化、配位化合物之熱力學、動力學、結構學、光譜學)及生醫科技之應用(組織專一性磁振造影劑、人造核酸限制脢、核醫藥劑、螢光分子探針)。

近期代表著作 :

  1. C.A. Chang*, Y.-L. Liu, C.-Y, Chen, X.-M. Chou, J.-S. Ho. “Ligand Preorganization in Metal Ion Complexation: Molecular Mechanics/Dynamics, Kinetics and the Laser-Excited Luminescence Studies of Trivalent Lanthanide Complex Formation with Macrocyclic Ligands DOTA and TETA”, Inorg. Chem., 2001, 40, 3448-3455. [SCI: 4.132; Rank: 4/43]
  2. C.A. Chang*, B.-H. Wu, P.-Y. Kuan. “Macrocyclic Lanthanide Complexes as Artificial Nucleases and Ribonucleases. Effects of pH, Metal Ionic Radii, Number of Coordinated Water Molecules, Charge and Concentrations of the Metal Complexes.” Inorg. Chem., 2005, 44, 6646-6654. [SCI: 4.132; Rank: 4/43]
  3. C.A. Chang*, Y.-P. Chen, C.-H. Hsiao. “Kinetics of BNPP Hydrolysis Reactions with Trivalent Lanthanide Complexes of N-Hydroxylethyl(ethylenediamine)-N,N’,N’-triacetate (HEDTA)”. Eur. J. Inorg. Chem., 2009, 1036-1042. [SCI: 2.597; Rank: 11/43]
  4. C.A. Chang*, C.-H. Hsiao, B.-H. Wu. “Effects of Concentration of Some Lanthanide(III) Complexes of 1,7-Bis(carboxymethyl)-1,4,7,10-tetraazacyclododecane (LnDO2A+) on BNPP Hydrolysis”, Eur. J. Inorg. Chem., 2009, 1339-1346. [SCI: 2.597; Rank: 11/43]

B. 生化工程及蛋白質化學、多醣生物化學:生化活性物質(多醣體、中草藥)之培育、分離、純化、大量表現、作用機理與結構及活性測試;惡性腫瘤、疾病辨識分子之研發; 骨骼(癌)細胞之生成與代謝。

近期代表著作 :

  1. K.-T. Chen, H.-F. Weng, C.A. Chang*, and E.-C. Chan*. “An Aberrant Autocrine Activation of the Platelet-derived Growth Factor α-Receptor in Follicular Thyroid Carcinoma Cell Line and Papillary Thyroid Carcinoma Cell Line.” Cancer Letters, 231 (2006) 192-205. [SCI: 3.398; Rank: 49/132].
  2. C.T. Lo, Y.-H. Jiang, A. L.-J. Chao, C.A. Chang*, “Use of statistical methods to interpret relationship between monosaccharide ratio and macrophage stimulatory activity of regionally different strains of Letinula Edodes”, Anal. Chim. Acta, 2007, 584, 50-56. [SCI: 3.186; Rank: 10/70].
  3. T.C.T. Lo, M.W. Kang, B.C. Wang, C.A. Chang*. “Glycosyl Linkage Characteristics and Classifications of Exo-polysaccharides of Some Regionally Different Strains of Lentinula edodes by Amplified Fragment Length Polymorphism Assay and Cluster Analysis”. Anal. Chim. Acta, 2007, 592, 146-153. [SCI: 3.186; Rank: 10/70].
  4. T.C.T. Lo, H.H. Tsao, A.Y. Wang, C.A. Chang*. “Pressurized Water Extraction of Polysaccharides as Secondary Metabolites from Lentinula edodes”. J. Agric. Food Chem., 2007, 55, 4196-4201. [SCI: 2.532; Rank: 1/35].
  5. S.-F. Chang, C.A. Chang*, D.-Y. Lee, P.-L. Lee, Y.-M. Yeh, C.-R. Yeh, C.-K. Cheng, S. Chien, J.-J. Chiu. “Tumor Cell Cycle Arrest Induced by Shear Stress: Roles of Integrins and Smad.” PNAS, 2008, 105, 3927-3932. [SCI: 9.598; Rank: 3/50].
  6. S.-F. Chang, C.-K. Cheng, S. Chien, C.A. Chang*, J.-J. Chiu*. “p21CIP1 and p27KIP1 are associated with Bone Morphogenetic Protein 4-induced osteoblast-like cell growth arrest and differentiation”. Mol. Endocrinol., 2009, in press. [SCI: 5.337; Rank: 13/92].
  7. Y.P. Kuo, C.A. Chang*, E.R. Chan*. “Identification and Clinical Associations of Anti-Cytokeratin 18 Autoantibody in Patients with Chronic Obstructive Pulmonary Disease". Eur. Respri. J., 2009, submitted (revision). [SCI: 5.545; Rank: 3/40].
  8. T.C.T. Lo, C.A. Chang*. “In Vitro Macrophage Stimulatory and Anti-tumor Activities and Enhancement of Macrophage Cell-Cell Communications of Polysaccharides from Some Regionally Different Strains of Lentinula edodes”, 2009, submitted (revision).

C. 生物分析化學、醫學工程:(奈米)生物檢測器、醫療診斷儀器、生物微機電。

近期代表著作 :

  1. S.-H. Lee, H.-Y. Fang, W.-C. Chen, H.-M. Lin, C.A. Chang*, “Electrochemical Study on the Screen-printed Carbon Electrodes with Modification by Iron Nanoparticles in Fe(CN)64-/3- Redox System.” Anal. Bioanal. Chem., 2005, 383:532-538. [SCI: 2.867; Rank: 17/70].
  2. Y.-H. Lin, T.Y. Shen, C.A. Chang*. “Reduction of the interferences of biochemicals and hematocrit ratio on the determination of whole blood glucose using multiple screen-printed carbon electrode (SPCE) test strips”, Anal. Bioanal. Chem., 2007, 389:1623-1631. [SCI: 2.867; Rank: 17/70].
  3. Y.-H. Lin, C.A. Chang*, C.S. Lin*, et al. “Amperometric immunosensing strips for the detection of foodborne pathogen Escherichia coli O157:H7 by Au nanoparticles-modified disposable screen printed carbon electrodes”, Biosensor & Bioelectronics, 2008, 23, 1832-1837. [SCI: 5.061; Rank: 3/70].
  4. Y.-H. Lin, Y.-C. Lu, S.-H. Chen, T.Y. Shen, C.-S. Lin*, C.A. Chang*. “Amperometric determinations of carbofuran and glutathione using screen-printed carbon electrode strips modified with gold nanoparticles, ferrocenedicarboxylic acid and tyrosinase”, 2009, submitted.